{"id":1031,"date":"2017-02-06T07:46:43","date_gmt":"2017-02-05T22:46:43","guid":{"rendered":""},"modified":"2019-09-27T11:39:32","modified_gmt":"2019-09-27T02:39:32","slug":"tvsiz","status":"publish","type":"post","link":"https:\/\/www.kusurinomadoguchi.com\/column\/articles\/tvsiz\/","title":{"rendered":"\u4eca\u307e\u3067\u306e\u7761\u7720\u85ac\u3068\u3069\u3046\u9055\u3046\uff1f\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u2460\u7279\u5fb4\u3068\u670d\u7528\u65b9\u6cd5"},"content":{"rendered":"<div class=\"article-item item_heading\">\n<h2 class=\"item-body\">\u76ee\u6b21\uff1a\u65b0\u3057\u3044\u7761\u7720\u85ac\u3079\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u2460\u7279\u5fb4\u3068\u57fa\u672c\u7684\u306a\u670d\u7528\u65b9\u6cd5<\/h2>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u25a0\u3053\u308c\u307e\u3067\u306e\u7761\u7720\u85ac<br \/>\u30fb\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u306e\u554f\u984c\u70b9<br 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class=\"item-body\">\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306f\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u8010\u6027\u3084\u4f9d\u5b58\u6027\u304c\u5f62\u6210\u3055\u308c\u306a\u3044\u3053\u3068\u304c\u5831\u544a<sup>\uff12\uff09<\/sup>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h2 class=\"item-body\">\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u670d\u7528\u65b9\u6cd5\u3084\u6ce8\u610f\u70b9<\/h2>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u3053\u3053\u304b\u3089\u306f\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u670d\u7528\u65b9\u6cd5\u3084\u6ce8\u610f\u70b9\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h3 class=\"item-body\">\u7528\u91cf\uff08\u4f7f\u7528\u91cf\uff09\u306b\u3064\u3044\u3066<\/h3>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u306f10mg\u300115mg\u300120mg\u306e3\u7a2e\u985e\u306e\u898f\u683c\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\uff0810mg\u306f2016\u5e7412\u6708\u306b\u65b0\u305f\u306b\u8ca9\u58f2\u958b\u59cb\uff09\u5148\u305a\u306f\u3001\u3053\u308c\u3089\u306e\u4f7f\u3044\u5206\u3051\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<br \/>\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u6dfb\u4ed8\u6587\u66f8\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u300e\u7528\u6cd5\u53ca\u3073\u7528\u91cf\u300f\u306e\u9805\u306b\u306f\u6b21\u306e\u3088\u3046\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_html\">\n<div class=\"item-body\">\u300e\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\u3068\u3057\u30661\u65e51\u56de20mg\u3092\u3001\u9ad8\u9f62\u8005\u306b\u306f1\u65e51\u56de15mg\u3092\u5c31\u5bdd\u76f4\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3002\u300f<sup>\uff13\uff09<\/sup><\/div>\n<\/div>\n<div class=\"article-item item_html\">\n<div class=\"item-body\">\u3064\u307e\u308a\u3001\u9ad8\u9f62\u8005<sup>\u203b<\/sup>\u306f15mg\u3001\u9ad8\u9f62\u8005\u4ee5\u5916\u306e\u65b9\u306f20mg\u3092\u57fa\u672c\u306b\u670d\u7528\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\uff08\u203b\u6dfb\u4ed8\u6587\u66f8\u306b\u304a\u3051\u308b\u9ad8\u9f62\u8005\u3068\u306f\u4e00\u822c\u306b65\u6b73\u4ee5\u4e0a\u306e\u65b9\u3092\u6307\u3057\u307e\u3059\uff09\u9ad8\u9f62\u8005\u306e\u65b9\u304c\u5c11\u306a\u3044\u91cf\u3092\u670d\u7528\u3059\u308b\u3088\u3046\u306b\u6c7a\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u9ad8\u9f62\u8005\u3068\u305d\u3046\u3067\u306a\u3044\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001\u9ad8\u9f62\u8005\u306e\u65b9\u304c\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u3001\u305d\u308c\u304c\u4e0b\u304c\u308b\u306e\u306b\u304b\u304b\u308b\u6642\u9593\uff08\u534a\u6e1b\u671f\uff09\u3082\u9577\u304f\u306a\u3063\u3066\u3044\u305f\u3053\u3068\u306b\u7531\u6765\u3057\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u305f\u3060\u3057\u3001\u9ad8\u9f62\u8005\u4ee5\u5916\u306e\u65b9\u3067\u3082\u75c7\u72b6\u306b\u5fdc\u3058\u306615mg\u3092\u670d\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h4 class=\"item-body\">\u4f75\u7528\u85ac\u306b\u5fdc\u3058\u3066\u4f7f\u7528\u3055\u308c\u308b10mg<\/h4>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u300c\u3042\u308c\uff1f20mg\u306815mg\u306e\u4f7f\u3044\u5206\u3051\u306f\u308f\u304b\u3063\u305f\u3051\u3069\u3001\u3082\u3046\uff11\u3064\u306e10mg\u306f\u3069\u3046\u3044\u3046\u6642\u306b\u4f7f\u3046\u306e\uff1f\u300d\u3068\u601d\u3044\u307e\u3059\u3088\u306d\u3002<br \/>\u5148\u306b\u8ff0\u3079\u305f\u3088\u3046\u306b10mg\u306f\u5f8c\u304b\u3089\u8ffd\u52a0\u3055\u308c\u305f\u898f\u683c\u3067\u3059\u300210mg\u306e\u4f7f\u3044\u5206\u3051\u306b\u3064\u3044\u3066\u306f\u6dfb\u4ed8\u6587\u66f8\u306e\u300e\u7528\u6cd5\u53ca\u3073\u7528\u91cf\u306b\u95a2\u9023\u3059\u308b\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u300f\u306b\u6b21\u306e\u3088\u3046\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_html\">\n<div class=\"item-body\">\u300eCYP3A\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264 (\u30b8\u30eb\u30c1\u30a2\u30bc\u30e0\u3001\u30d9\u30e9\u30d1\u30df\u30eb\u3001\u30d5\u30eb\u30b3\u30ca\u30be\u30fc\u30eb\u7b49) \u3068\u306e\u4f75\u7528\u306b\u3088\u308a\u3001\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u50be\u7720\u3001\u75b2\u52b4\u3001\u5165\u7720\u6642\u9ebb\u75fa\u3001\u7761\u7720\u6642\u968f\u4f34\u75c7\u3001\u5922\u904a\u75c7\u7b49\u306e\u526f\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u4f75\u7528\u3059\u308b\u5834\u5408\u306f1\u65e51\u56de10mg\u3078\u306e\u6e1b\u91cf\u3092\u8003\u616e\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u60a3\u8005\u306e\u72b6\u614b\u3092\u614e\u91cd\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3002\u300f<sup>\uff13\uff09<\/sup><\/div>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u3042\u3068\u3067\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u304c\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u98f2\u307f\u5408\u308f\u305b\u304c\u5b58\u5728\u3057\u3001\u305d\u306e\u98f2\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u306e\u6709\u52b9\u6210\u5206\u3067\u3042\u308b\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u3059\u304e\u3066\u3057\u307e\u3046\u3068\u3001\u671f\u5f85\u3059\u308b\u52b9\u679c\u4ee5\u5916\u306e\u526f\u4f5c\u7528\u304c\u51fa\u73fe\u3057\u3066\u3057\u307e\u3046\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u3067\u3059\u306e\u3067\u3001\u305d\u3046\u3044\u3063\u305f\u98f2\u307f\u5408\u308f\u305b\u304c\u751f\u3058\u308b\u5834\u5408\u306f\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u3092\u5c11\u306a\u3081\u306e10mg\u306b\u3059\u308b\u3053\u3068\u3067\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u3059\u304e\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h3 class=\"item-body\">\u98f2\u307f\u65b9\uff08\u7528\u6cd5\uff09\u306b\u3064\u3044\u3066<\/h3>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u4e0a\u306b\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306f\uff11\u65e5\uff11\u56de\u3001\u5bdd\u308b\u76f4\u524d\u306b\uff11\u9320\u3092\u670d\u7528\u3057\u307e\u3059\u3002<\/p>\n<p>\u670d\u7528\u5f8c\u306f\u52b9\u679c\u306e\u6301\u7d9a\u3059\u308b\u671d\u307e\u3067\u7720\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u9014\u4e2d\u3067\u4e00\u5ea6\u8d77\u304d\u3066\u4ed5\u4e8b\u7b49\u3092\u884c\u3046\u5834\u5408\u306f\u670d\u7528\u3059\u308b\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u307e\u305f\u3001\u3082\u3046\u4e00\u3064\u5927\u4e8b\u306a\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066\u3001\u98df\u4e8b\u4e2d\u3084\u98df\u4e8b\u306e\u76f4\u5f8c\u306e\u670d\u7528\u306f\u907f\u3051\u308b\u3088\u3046\u306b\u3057\u307e\u3057\u3087\u3046\u3002\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u6709\u52b9\u6210\u5206\u3067\u3042\u308b\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\u306e\u8840\u4e2d\u6fc3\u5ea6\u306f\u670d\u7528\u5f8c\uff11\u301c\uff12\u6642\u9593\u5f8c\u306b\u30d4\u30fc\u30af\u3092\u8fce\u3048\u307e\u3059\u3002\u3067\u3059\u304c\u3001\u98df\u4e8b\u306e\u5f8c\u306b\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u3092\u670d\u7528\u3059\u308b\u3068\u305d\u306e\u6642\u9593\u304c\uff11\u6642\u9593\u304f\u3089\u3044\u9045\u308c\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30b9\u30e0\u30fc\u30ba\u306a\u5165\u7720\u52b9\u679c\u3092\u671f\u5f85\u3067\u304d\u308b\u3088\u3046\u306b\u670d\u7528\u524d\uff08\u7761\u7720\u524d\uff09\u306e\u98df\u4e8b\u306f\u907f\u3051\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u306e\u3067\u3059\u3002<\/p><\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h2 class=\"item-body\">\u304a\u308f\u308a\u306b<\/h2>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">\u4eca\u56de\u306f\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u306e\u7279\u5fb4\u3084\u57fa\u672c\u7684\u306a\u670d\u7528\u65b9\u6cd5\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u307f\u307e\u3057\u305f\u3002\u6b21\u56de\u306f\u6c17\u306b\u306a\u308b\u526f\u4f5c\u7528\u3084\u98f2\u307f\u5408\u308f\u305b\u3001\u305d\u306e\u307b\u304b\u306e\u6ce8\u610f\u70b9\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/div>\n<\/div>\n<div class=\"article-item item_heading\">\n<h2 class=\"item-body\">\u53c2\u8003<\/h2>\n<\/div>\n<div class=\"article-item item_text\">\n<div class=\"item-body-hbr\">1\uff09Gotter AL et al. Pharmacol Rev 2012;64(3):389-420\u2028<br \/>2\uff09\u30d9\u30eb\u30bd\u30e0\u30e9\u9320 \u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u30d5\u30a9\u30fc\u30e0 MSD\u682a\u5f0f\u4f1a\u793e<br \/>3\uff09\u30d9\u30eb\u30bd\u30e0\u30e9\u9320\u6dfb\u4ed8\u6587\u66f8 MSD\u682a\u5f0f\u4f1a\u793e<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u76ee\u6b21\uff1a\u65b0\u3057\u3044\u7761\u7720\u85ac\u3079\u30eb\u30bd\u30e0\u30e9\u00ae\u9320\u2460\u7279\u5fb4\u3068\u57fa\u672c\u7684\u306a\u670d\u7528\u65b9\u6cd5 \u25a0\u3053\u308c\u307e\u3067\u306e\u7761\u7720\u85ac\u30fb\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u306e\u554f\u984c\u70b9\u25a0\u4e16\u754c\u521d\u306e\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u5264\u30d9\u30eb\u30bd\u30e0\u30e9\u00ae\u30fb\u899a\u9192\u3092\u53f8\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u30aa\u30ec\u30ad\u30b7\u30f3\u30fb\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u50cd\u304d\u30fb\u30d9\u30eb\u30bd &#8230;<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10312],"tags":[1389,50,91],"class_list":["post-1031","post","type-post","status-publish","format-standard","hentry","category-10312","tag-1389","tag-50","tag-91"],"_links":{"self":[{"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/posts\/1031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/comments?post=1031"}],"version-history":[{"count":0,"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/posts\/1031\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/media?parent=1031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/categories?post=1031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kusurinomadoguchi.com\/column\/wp-json\/wp\/v2\/tags?post=1031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}