{"id":710,"date":"2016-08-17T01:48:02","date_gmt":"2016-08-16T16:48:02","guid":{"rendered":""},"modified":"2019-09-26T09:29:37","modified_gmt":"2019-09-26T00:29:37","slug":"s3b8w","status":"publish","type":"post","link":"https:\/\/www.kusurinomadoguchi.com\/column\/articles\/s3b8w\/","title":{"rendered":"\u3010\u57fa\u790e\u77e5\u8b58\u3011\u6297\u304c\u3093\u5264\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u52b9\u679c\u30683\u3064\u306e\u7279\u5fb4\u7684\u306a\u526f\u4f5c\u7528"},"content":{"rendered":"
\n

\u30a2\u30d0\u30b9\u30c1\u30f3\u3068\u306f\uff1f<\/h2>\n<\/div>\n
\n
\u30a2\u30d0\u30b9\u30c1\u30f3\u306f\u5927\u8178\u304c\u3093\u3084\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306b\u7528\u3044\u308b\u6ce8\u5c04\u85ac\u3067\u3059\u3002<\/div>\n<\/div>\n
\n

\u6709\u52b9\u6210\u5206\u306f\u30d9\u30d0\u30b7\u30ba\u30de\u30d6<\/h3>\n<\/div>\n
\n
\u30a2\u30d0\u30b9\u30c1\u30f3\u306b\u542b\u307e\u308c\u308b\u6709\u52b9\u6210\u5206\u306f\u300c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u300d\u3068\u8a00\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u300c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50 (VEGF)\u300d\u3068\u7d50\u5408\u3059\u308b\u6297\u4f53\u3092\u4eba\u5de5\u7684\u306b\u85ac\u306b\u3057\u305f\u3082\u306e\u3067\u3059 (1)\u3002<\/p>\n

\u300c\u6297\u4f53\u300d\u3068\u306f\u3001\u514d\u75ab\u3092\u62c5\u5f53\u3059\u308b\u7269\u8cea\u306e\u4e00\u7a2e\u3067\u3001\u75c5\u539f\u4f53\u306e\u8868\u9762\u306b\u3042\u308b\u7269\u8cea\u306a\u3069\u306b\u304f\u3063\u3064\u3044\u3066\u3001\u3053\u308c\u3092\u6392\u9664\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u6297\u4f53\u304c\u304f\u3063\u3064\u3044\u305f\u7269\u8cea\u306f\u3001\u305d\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u305f\u308a\u3001\u5f31\u304f\u306a\u3063\u305f\u308a\u3059\u308b\u306e\u3067\u3059\u3002<\/p><\/div>\n<\/div>\n

\n

\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306fVEGF\u306e\u6a5f\u80fd\u3092\u90aa\u9b54\u3059\u308b\u85ac<\/h3>\n<\/div>\n
\n
\u3057\u305f\u304c\u3063\u3066\u3001\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306fVEGF\u306e\u6a5f\u80fd\u3092\u90aa\u9b54\u3059\u308b\u85ac\u3067\u3059\u3002
\u3067\u306f\u3001\u3053\u306eVEGF\u3068\u306f\u4e00\u4f53\u3069\u306e\u3088\u3046\u306a\u50cd\u304d\u3092\u3059\u308b\u3082\u306e\u306a\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/div>\n<\/div>\n
\n

VEGF\u3068\u306f\uff1f<\/h2>\n<\/div>\n
\n

VEGF\u306f\u304c\u3093\u7d30\u80de\u306e\u6210\u9577\u306b\u5fc5\u8981\u306a\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea<\/h3>\n<\/div>\n
\n
\u5c02\u9580\u7684\u306b\u8a00\u3048\u3070\u3001VEGF\u306f\u304c\u3093\u7d30\u80de\u306e\u6210\u9577\u306b\u5fc5\u9808\u306a\u3001\u8108\u7ba1\u5f62\u6210\u3068\u8840\u7ba1\u65b0\u751f\u306b\u95a2\u4e0e\u3059\u308b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059 (2)\u3002<\/p>\n

\u3053\u308c\u3067\u306f\u4f55\u306e\u3053\u3068\u304b\u308f\u304b\u3089\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3089\u3001\u3082\u3046\u5c11\u3057\u565b\u307f\u7815\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002
\u7d30\u80de\u304c\u751f\u304d\u3066\u3044\u304f\u3046\u3048\u3067\u3001\u8840\u6db2\u304c\u5fc5\u305a\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u306f\u3054\u5b58\u77e5\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u8840\u6db2\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u306b\u5fc5\u8981\u306a\u9178\u7d20\u3084\u6804\u990a\u304c\u4f9b\u7d66\u3055\u308c\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u3053\u308c\u307e\u305f\u3054\u5b58\u77e5\u306e\u901a\u308a\u3001\u304c\u3093\u7d30\u80de\u306f\u7121\u9650\u306e\u5897\u6b96\u80fd\u529b\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u304c\u3093\u7d30\u80de\u3068\u3066\u3001\u8840\u6db2\u306b\u3088\u308b\u9178\u7d20\u3068\u6804\u990a\u306e\u88dc\u7d66\u306a\u3057\u306b\u306f\u751f\u304d\u3066\u3044\u304f\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n

\u3057\u304b\u3082\u3001\u304c\u3093\u7d30\u80de\u306f\u5e38\u306b\u5927\u304d\u304f\u306a\u308d\u3046\u3068\u3059\u308b\u6027\u8cea\u304c\u3042\u308a\u307e\u3059\u304b\u3089\u3001\u5fc5\u8981\u3068\u3059\u308b\u9178\u7d20\u3084\u6804\u990a\u3082\u52a0\u901f\u5ea6\u7684\u306b\u5897\u3048\u3066\u3044\u304d\u307e\u3059\u3002\u3053\u3046\u306a\u308b\u3068\u3001\u3042\u308b\u3068\u3053\u308d\u3067\u65e2\u5b58\u306e\u8840\u7ba1\u3060\u3051\u3067\u306f\u8db3\u308a\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u305d\u3053\u3067\u3001\u304c\u3093\u7d30\u80de\u306f\u3001\u81ea\u5206\u306b\u5fc5\u8981\u306a\u8840\u7ba1\u3092\u65b0\u3057\u304f\u4f5c\u308a\u51fa\u3059\u6a5f\u80fd\u3092\u6301\u3063\u305f\u7269\u8cea\u3092\u5206\u6ccc\u3057\u307e\u3059\u3002\u3053\u308c\u304cVEGF\u3067\u3059\u3002\u73fe\u5728\u3067\u306f\u3001\u69d8\u3005\u306a\u7a2e\u985e\u306e\u304c\u3093\u7d30\u80de\u304c\u3001VEGF\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u4f8b\u3048\u3070\u80c3\u304c\u3093\u3001\u5927\u8178\u304c\u3093\u3001\u80ba\u304c\u3093\u306a\u3069\u3067\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059 (3-5)\u3002<\/p><\/div>\n<\/div>\n

\n

VEGF\u306e\u306f\u305f\u3089\u304d\u3092\u9053\u8def\u5de5\u4e8b\u306b\u4f8b\u3048\u3066\u89e3\u8aac<\/h3>\n<\/div>\n
\n
\u9053\u8def\u5de5\u4e8b\u3092\u8003\u3048\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/div>\n<\/div>\n
\n
\u305d\u306e\u5efa\u8a2d\u306f\u5927\u304d\u304f\u5206\u3051\u3066\u3001<\/p>\n

1. \u3053\u308c\u307e\u3067\u9053\u8def\u304c\u306a\u304b\u3063\u305f\u5834\u6240\u306b\u3001\u30bc\u30ed\u304b\u3089\u4f5c\u308b
2. \u3059\u3067\u306b\u51fa\u6765\u4e0a\u304c\u3063\u305f\u9053\u8def\u3092\u5ef6\u9577\u3059\u308b
\u306e2\u901a\u308a\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8840\u7ba1\u3092\u4f5c\u308b\u5834\u5408\u306b\u3082\u305d\u306e\u307e\u307e\u5f53\u3066\u306f\u307e\u308a\u30011\u3092\u300c\u8108\u7ba1\u5f62\u6210\u300d\u3068\u30012\u3092\u300c\u8840\u7ba1\u65b0\u751f\u300d\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001
\u25cf\u8108\u7ba1\u5f62\u6210\uff1a\u3053\u308c\u307e\u3067\u8840\u7ba1\u304c\u306a\u304b\u3063\u305f\u90e8\u4f4d\u306b\u3001\u65b0\u3057\u304f\u8840\u7ba1\u3092\u4f5c\u308b
\u25cf\u8840\u7ba1\u65b0\u751f\uff1a\u3059\u3067\u306b\u3042\u308b\u8840\u7ba1\u3092\u5ef6\u9577\u3057\u305f\u308a\u3001\u679d\u5206\u304b\u308c\u3092\u4f5c\u3063\u305f\u308a\u3059\u308b<\/p>\n

\u3068\u8a00\u3046\u3053\u3068\u3067\u3001VEGF\u306f\u3053\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u306f\u305f\u3089\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p><\/div>\n<\/div>\n

\n

\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u52b9\u679c\u3068\u4f7f\u3044\u65b9<\/h2>\n<\/div>\n
\n
\n
<\/a><\/div>\n
\n

<\/h4>\n<\/div>\n<\/div>\n<\/div>\n
\n
\u30a2\u30d0\u30b9\u30c1\u30f3\u306f\u3001\u70b9\u6ef4\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u85ac\u3067\u3001\u901a\u5e38\u306f2-3\u9031\u306e\u9593\u9694\u3067\u6295\u4e0e\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u3053\u307e\u3067\u8aad\u307f\u9032\u3081\u3066\u304d\u305f\u65b9\u306f\u3059\u3067\u306b\u304a\u6c17\u3065\u304d\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u30a2\u30d0\u30b9\u30c1\u30f3\u81ea\u4f53\u306b\u3001\u304c\u3093\u7d30\u80de\u3092\u58ca\u3059\u52b9\u679c\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u3057\u305f\u304c\u3063\u3066\u3001\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u5358\u72ec\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u307e\u305a\u306a\u304f\u3001\u305f\u3044\u3066\u3044\u306f\u304c\u3093\u7d30\u80de\u3092\u76f4\u63a5\u58ca\u3059\u52b9\u679c\u3092\u6301\u3063\u305f\u3001\u4ed6\u306e\u6297\u304c\u3093\u5264\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p><\/div>\n<\/div>\n

\n

\u30a2\u30d0\u30b9\u30c1\u30f3\u304c\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u75c5\u6c176\u7a2e\u985e<\/h2>\n<\/div>\n
\n
2016\u5e748\u6708\u73fe\u5728\u3067\u3001\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u9069\u5fdc\u75c7\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059 (1)\u3002<\/p>\n

\u25cf\u7d50\u8178\u30fb\u76f4\u8178\u304c\u3093 (\u5207\u9664\u4e0d\u53ef\u80fd\u306a\u9032\u884c\u30fb\u518d\u767a\u306e\u3082\u306e)
\u25cf\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093 (\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u3092\u9664\u304f\u3001\u624b\u8853\u4e0d\u53ef\u80fd\u306a\u9032\u884c\u30fb\u518d\u767a\u306e\u3082\u306e)
\u25cf\u5375\u5de3\u304c\u3093
\u25cf\u5b50\u5bae\u9838\u304c\u3093 (\u9032\u884c\u307e\u305f\u306f\u518d\u767a\u3057\u305f\u3082\u306e)
\u25cf\u4e73\u304c\u3093 (\u624b\u8853\u4e0d\u53ef\u80fd\u307e\u305f\u306f\u9032\u884c\u3057\u305f\u3082\u306e)
\u25cf\u60aa\u6027\u795e\u7d4c\u81a0\u816b<\/p>\n

\u3053\u308c\u3089\u306b\u5bfe\u3057\u3066\u3001\u3053\u308c\u307e\u3067\u884c\u308f\u308c\u3066\u304d\u305f\u6cbb\u7642\u6cd5\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u4e0a\u4e57\u305b\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u679c\u3092\u3088\u304f\u3059\u308b\u306e\u304c\u3001\u57fa\u672c\u7684\u306a\u4f7f\u3044\u65b9\u3067\u3059\u3002<\/p>\n

\u4f8b\u5916\u3068\u3057\u3066\u3001\u6700\u5f8c\u306e\u6319\u3052\u305f\u300c\u60aa\u6027\u795e\u7d4c\u81a0\u816b (\u30b0\u30ea\u30aa\u30fc\u30de)\u300d\u3068\u8a00\u3046\u75c5\u6c17\u3067\u306f\u3001\u518d\u767a\u3057\u305f\u969b\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u5358\u72ec\u4f7f\u7528\u3057\u305f\u5834\u5408\u306e\u6709\u52b9\u6027\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059 (6)\u3002<\/p><\/div>\n<\/div>\n

\n

\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u52b9\u679c\u306e\u4f8b<\/h3>\n<\/div>\n
\n
\u52b9\u679c\u306e\u4e00\u4f8b\u3068\u3057\u3066\u3001\u80ba\u304c\u3093\u6cbb\u7642\u306b\u5bfe\u3057\u3066\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u4e0a\u4e57\u305b\u3057\u305f\u5834\u5408\u3001\u3057\u306a\u304b\u3063\u305f\u5834\u5408\u3068\u6bd4\u8f03\u3057\u3066\u3001\u304c\u3093\u304c\u9032\u884c\u305b\u305a\u306b\u5b89\u5b9a\u3057\u305f\u72b6\u614b\u306b\u3042\u308b\u671f\u9593 (\u3053\u308c\u3092\u300c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u300d\u3068\u547c\u3073\u307e\u3059) \u304c\u30012\u304b\u6708\u534a\u307b\u3069\u5ef6\u9577\u3059\u308b\u3001\u3068\u8a00\u3046\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u304c\u3042\u308a\u307e\u3059 (7)\u3002<\/p>\n

\u3053\u308c\u3060\u3068\u3001\u3084\u3084\u52b9\u679c\u304c\u5fc3\u3082\u3068\u306a\u304f\u611f\u3058\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u5f8c\u8ff0\u3079\u308b\u526f\u4f5c\u7528\u306a\u3069\u3092\u52a0\u5473\u3057\u3066\u3001\u4f7f\u3046\u304b\u3069\u3046\u304b\u3092\u6c7a\u3081\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p><\/div>\n<\/div>\n

\n

\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u526f\u4f5c\u7528<\/h2>\n<\/div>\n
\n
\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u3088\u3046\u306b\u3001\u304c\u3093\u3084\u8eab\u4f53\u306b\u5b58\u5728\u3059\u308b\u7279\u5b9a\u306e\u7269\u8cea (\u5206\u5b50) \u306b\u30d4\u30f3\u30dd\u30a4\u30f3\u30c8\u3067\u4f5c\u7528\u3059\u308b\u85ac\u3092\u300c\u5206\u5b50\u6a19\u7684\u85ac\u300d\u3068\u547c\u3073\u307e\u3059\u3002\u5206\u5b50\u6a19\u7684\u85ac\u306f\u3001\u30a2\u30d0\u30b9\u30c1\u30f3\u4ee5\u5916\u306b\u3082\u305f\u304f\u3055\u3093\u306e\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u526f\u4f5c\u7528\u306b\u3082\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u6297\u304c\u3093\u5264\u306e\u526f\u4f5c\u7528\u3068\u805e\u3051\u3070\u3001\u305f\u3044\u3066\u3044\u306f\u8131\u6bdb\u30fb\u5410\u304d\u6c17\u30fb\u767d\u8840\u7403\u6e1b\u5c11\u306a\u3069\u3092\u601d\u3044\u6d6e\u304b\u3079\u308b\u3053\u3068\u3067\u3057\u3087\u3046\u3002<\/p>\n

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\n
\n
<\/a><\/div>\n
\n

<\/h4>\n<\/div>\n<\/div>\n<\/div>\n
\n
\u3053\u306e\u3046\u3061\u3001\u6d88\u5316\u7ba1\u7a7f\u5b54\u306f\u307e\u308c\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u6b7b\u4ea1\u4f8b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u70b9\u3067\u91cd\u8981\u3067\u3059 (1)\u3002
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\n

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\n
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\n

\u307e\u3068\u3081<\/h2>\n<\/div>\n
\n
\u25a0\u30a2\u30d0\u30b9\u30c1\u30f3\u306f\u300c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u300d\u3068\u8a00\u3046\u6709\u52b9\u6210\u5206\u3092\u542b\u3080\u6297\u304c\u3093\u5264\u3067\u3042\u308b
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\u25a0\u5358\u72ec\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u307e\u308c\u3067\u3001\u4ed6\u306e\u6297\u304c\u3093\u5264\u3068\u4f75\u7528\u3057\u3066\u305d\u306e\u52b9\u679c\u3092\u9ad8\u3081\u308b\u306e\u304c\u57fa\u672c\u3067\u3042\u308b
\u25a0\u526f\u4f5c\u7528\u3068\u3057\u3066\u3001\u6d88\u5316\u7ba1\u7a7f\u5b54\u3084\u9ad8\u8840\u5727\u304c\u7279\u5fb4\u7684\u3067\u3042\u308b<\/div>\n<\/div>\n
\n

\u53c2\u8003\u6587\u732e<\/h2>\n<\/div>\n
\n
(1) \u30a2\u30d0\u30b9\u30c1\u30f3\u70b9\u6ef4\u9759\u6ce8\u7528\u3000\u6dfb\u4ed8\u6587\u66f8\u3000\u4e2d\u5916\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e
(2) Ruiz de Almodovar C, et al. Role and therapeutic potential of VEGF in the nervous system. Physiol Rev. 2009 Apr;89(2):607-48. PMID: 19342615
(3) Maeda K, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer. 1996 Mar 1;77(5):858-63. PMID: 8608475
(4) Lee JC, et al. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer. 2000 Apr;36(6):748-53. PMID: 10762747
(5) Fontanini G, et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res. 1997 Jun;3(6):861-5. PMID: 9815760<\/div>\n<\/div>\n
\n
(6) Friedman HS, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009 Oct 1;27(28):4733-40. PMID: 19720927
(7) Zhou C, et al. BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter,Phase III Study of First-Line Carboplatin\/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small- Cell Lung Cancer. J ClinOncol. 2015 Jul 1;33(19):2197-204. PMID: 26014294
(8) Hapani S, et al. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol. 2009 Jun;10(6):559-68. PMID: 19482548
(9) Roohullah A, et al. Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab. World J Gastroenterol. 2015 May 7;21(17):5352-8. PMID: 25954110<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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